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We still dont know if regularly boosting glutathione in humans leads to better long-term health outcomes

Respiratory ( respiratory depression, apnea, shallow breathing ) Endocrine (hyperglycemia) Eye (miosis) Severe necrotic skin ulcerations have been documented in patients who inject illicit street drugs containing xylazine (Malayala et al, 2022

Importantly, low Se levels in pregnant women affect fetal growth and augment the risk of delivering a small-for-gestational age infant by reducing placental antioxidant defense, while low Se in the third trimester is thought to indicate increased demands by the placenta, an issue which requires further confirmation

At the cellular level, glutathione functions as a cofactor for antioxidant enzymes like glutathione peroxidase and glutathione-S-transferase, which neutralize reactive oxygen species and support phase-II detoxification pathways