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Curr Opin Pulm Med 26(4):363371

The disposition profiles of three of the six major kavalactones (kavain, methysticin and desmethoxyyangonin) and their respective metabolites (p-hydroxykavain, m,p-dihydroxykavain and p-hydroxy-5,6-dehydrokavain) were examined in the perfusate and bile of the isolated perfused rat liver by Fu et al (Fu et al., 2012)

Patients have injected five to twenty times their intended dose because they confused units, milligrams, and milliliters

Despite these doubts, clinical correlation data and studies on the consequences of iron overload from other diseases, led to the widespread recommendation to treat transfusion-induced iron overload in patients with hematological malignancies