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Well, in Brasil, they are not given saline solution, if BBC is to be trusted

139 It must be stated that metformin is a very effective drug in terms of improving glycaemic control, which itself reduces peripheral nerve damage and indeed several animal studies have indicated that it can have non-glycaemic related antineuropathic and neuroprotective effects

In the study of ob/ob mice (an obese mouse model), AOD 9604 at a dose of 250 g/kg was administered daily

(7) These are observational cohorts with their own populations, confounders, and limits, so the numbers describe an association in a group, not a prediction for an individual