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Furthermore, taking advantage of the FAH knockout mouse model, we tested for Itfg1 knockdown driven faster liver repopulation, enhanced regeneration after partial hepatectomy and fibrosis reduction in chronic liver damaging conditions, including Western Diet driven NAFLD

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In the early stages of DKD, increased hyper-reabsorption and gluconeogenesis expose proximal tubular cells to hypoxia, resulting in mitochondrial dysfunction, increased oxidative stress and tubular injury (39)