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In renal epithelial cells, TRPV4 channel activation results mainly from hypotonic cell swelling, which suggests that TRPV4 acts as an osmosensor and could play a critical role in renal ischemic/reperfusion injury 41,42 and in autosomal recessive polycystic kidney disease 43

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Main text Antioxidants overview While this manuscript focuses on the effect of antioxidants as adjuvant therapy in patients with CAP, it is important to note that the available studies specifically addressing CAP are limited

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