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Retrieved 18 March 2008

More importantly, activation of TGF- in the right place at the right time is necessary to recruit stem/progenitor cells to participate in the tissue regeneration/remodeling process, whereas sustained abnormalities in TGF- ligand expression, bioavailability, activation, receptor assemblage/stabilization, or post-transcriptional modifications will inevitably disrupt the normal physiology, and lead to pathobiology of major diseases either through the recruitment of excessive progenitors (as seen in osteoarthritis or CamuratiEngelmann disease), or trans-differentiation of resident cells to unfavorable lineage commitment (as seen in epithelial to mesenchymal transition during cancer metastasis or tissue/organ fibrosis)

Each of these elements (fire for summer, earth for late summer, metal for autumn, water for winter, and wood for spring) controls certain organs in the body

Theyre wanting a certain amount of certitude that, frankly, is appropriate for most drugs, but not for this moment. Regulatory shortcuts exist that would allow the FDA to skip the more laborious approval process