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Apart from these protein families, the SH2-domain containing LNK (SH2B3) adaptor protein has been shown to be an important negative regulator in the JAKSTAT pathway

To illustrate, Liu et al

13 Other studies in patients with rheumatoid arthritis have shown induction of antinuclear antibody and anti-dsDNA after the use of infliximab and etanercept

It further suggests that rutin and aescin mimic the effects of the standard antithyroid medication PTU, potentially via mechanisms documented in prior studies, including modulation of 5-deiodinase activity 60,61