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It is suggested that only the uncharged, protonated form can cross cell membranes (Kawai et al., 2006

Analyses of horse samples were carried out at the Freie Universitt Berlin

These drugs are commonly referred to as biased ligands. For instance, G protein-biased -opioid receptor (OR) agonists are of remarkable clinical relevance as they enhance analgesia effects and reduce adverse reactions associated with the activation of -arrestin pathways, in contrast to morphine