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Holton [email protected] This article was submitted to Mood Disorders, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Instead, the researchers found that one of its metabolic breakdown productsthe smaller fragment Ac-LKKTEwas responsible for the biological activity, suggesting that the entire pharmacological understanding of how TB-500 operates may be flawed or incomplete

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