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Normal resting cells with low NADPH consumption have a relatively low NADP + /NADPH ratio, possibly explaining why G6PDH activity is relatively low despite high expression levels in some tissues

Korbling M, Huh YO, Durett A, Mirza N, Miller P, Engel H, Anderlini P, van Besien K, Andreeff M , Przepiorka D, Deisseroth AB, Champlin RE

However, numerous preclinical and clinical studies involving these innovations have failed to account for the fundamental limitations in current antioxidant testing approaches

The metabolic coupling for taurine synthesis and degradation between astrocytes and neurons, evidence neuronal dependence on astrocytes for the adequate functioning of the mentioned effects in the brain