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non-motor symptoms include autonomic dysfunction, sleep disorders, cognitive abnormalities, and constipation, see the reviews by Most PD cases are sporadic and approximately 10% of cases are inherited (Yoo et al., 2018)

doi: 10.1371/journal.pone.0196570 28 LenzenSDrinkgernJTiedgeM

Hepatoma cell lines typically lack the CYP450 activity to generate the reactive metabolite of APAP observed in vivo, but are still subject to APAP cytotoxicity