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For the vascular side, GHK-Cu promotes angiogenesis through VEGF and bFGF expression, improves blood vessel integrity, and supports microcirculation

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Although years of continuous research have revealed a variety of possible pathogeneses for the development of NP and proposed many treatment methods, most people have ignored the importance of the opioid system in NP due to the low therapeutic efficacy, complex side effects, and high analgesic tolerance of opioids [10,11,12,13,14]

KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination