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BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy

341 Skin flap necrosis, a rising factor in the poor prognosis of patients after flap transplantation, is closely related to endothelial-to-mesenchymal transition (EndoMT), which is exacerbated by glycolysis-derived lactate production

Each treatment had 5 biological replicates sent out for metabolic analysis

T315I-Bcr-Abl-32D cells have high dTTP pool and low replication stress with increased GSH biosynthesis To understand the underlying mechanism for the differential susceptibility to JMF4073 in these cells, we performed quantitative analysis of four dNTPs