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H 2 O 2 produced by NADPH-cytochrome P450 reductase generates free radicals catalyzed by Fe 2+ (Zhang et al

That is, ATP was elevated more than ADP, as can be seen from the ATP/ADP ratio, which suggests that an increase in the adenine nucleotide pool activates the production of more ATP

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By employing physical encapsulation or chemical conjugation, these platforms circumvent the physicochemical limitations inherent to many PROTACs, thereby liberating medicinal chemistry efforts from the empirical correction of poor drug-like properties and enabling a sharper focus on optimizing the ternary complex for maximal degradation activity [56, 276,277,278]