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First, animal model development should prioritize the physiological and behavioral relevance to human tinnitus, incorporating refined induction protocols, cross-species validation, and translational biomarkers measurable in both preclinical and clinical settings

In: Pagon RA, Adam MP, Ardinger HH, et al., editors

Concerns about adverse effects, particularly the risk of dependence, and reports of tinnitus exacerbation upon discontinuation 115 indicate the need for caution, and future research could clarify whether specific patient subgroups might benefit from targeted, short-duration BZD therapy under strict clinical supervision