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Description

DHPA, an antioxidant and anti-inflammatory substance, inhibited A1-42/Cu 2+ /ascorbic acid-induced oxidative damages by regulating mitochondrial apoptosis in human neuroblastoma SH-SY5Y cells, inducing the KEAP1/Nrf2/HO-1 signaling axis and enhancing the expression of NQO1 [123]

Minor contributions to drug metabolism have been observed in vitro from CYP1A1, CYP2C8, and CYP2C18, though these enzymes are less relevant in vivo due to their lower hepatic expression compared to CYP3A4 (Shimada et al., 1994)