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Combining ferroptosis inducers with immune checkpoint inhibitors, such as anti-CTLA4 (cytotoxic T-lymphocyte associated protein 4), anti-PDCD1/PD-1 (programmed cell death 1), or anti-CD274/PD-L1 (programmed death ligand 1) antibodies, enhances tumor suppression compared to using immune checkpoint inhibitors alone

However, based on previous case reports, RTX has shown better efficacy and fewer side effects

The glutathione reductase inhibitor (GRI) 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid hydrate (2-AAPA) was purchased from Sigma-Aldrich