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As of now, clinical trials combining bispecific antibodies with hyaluronidase are in full swing, particularly the star product Rybrevant (amivantamab) from Johnson & Johnson, which is being administered in a fixed subcutaneous combination with recombinant human hyaluronidase

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Nevertheless, cGAS has been found to directly suppress DNA repair [76, 77], mechanistically in tumorigenesis by directly binding cGAS to DDR components inside the cell nucleus