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763 Activated SIRT1 ameliorated LC3 deacetylation-mediated autophagic degradation of -synuclein and improved motor defects and pathological changes in PD mice

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Exercise, diet or a combination of both can reduce T2D risk by 3060% according to large-scale RCT trials (the IDPP, DPP, FDPS, and Da Qing trials), and the variation in the reduction rate may be due to differences in the population in those trials, while people with a greater BMI and older age had a greater reduction in T2D risk