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Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation

It is understood that blood components such as red blood cells will be removed and reintroduced to the circulatory system

To address this limitation, the study was re-conducted using an IMR-5 (MNA) xenograft immunodeficient NB mouse model, where a reduced toxicity was observed ( Figures 9A, C )