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TAT-CcSOD1 also exhibited a remarkable stability in pH ranging from 5.0 to 9.0, and retained approximately 50% activity in pH 10.0 for 2 h (Fig

Under inflammatory conditions, pro-inflammatory cytokines [e.g., interferon-gamma (IFN-)] can activate IDO1, diverting Trp metabolism toward the kynurenine (KYN) pathway while inhibiting 5-HT synthesis, resulting in serotonin depletion and exacerbation of neurotransmitter imbalance (Rus et al., 2015)