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Description

Metformin Suppresses Lipopolysaccharide (LPS)-Induced Inflammatory Response in Murine Macrophages Via Activating Transcription Factor-3 (ATF-3) Induction

doi: 10.1016/j.phanu.2024.100423 527 SinghTPNatrajBH

The unmodified FXa comprises a light chain consisting of the amino acid sequence shown as residues 1-139 of SEQ ID NO: 134, and a heavy chain consisting of the amino acid sequence shown as residues 195 -448 of SEQ ID NO: 134, wherein: the modified FXa has at least a 50-fold increased Fa cofactor dependence compared to the unmodified FXa polypeptide that does not contain the amino acid substitution