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This pathogenic process is further influenced by oxidative and endoplasmic reticulum stress, GM dysbiosis, disruptions in genetic and epigenetic regulation, mitochondrial dysfunction, as well as various environmental and dietary determinants [8]

Theor Appl Genet 91:802808 Traka M, Gasper AV, Smith JA et al (2005) Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane

Curr Opin Plant Biol 5:388395 Panchuk II, Volkov RA, Schffl F (2002) Heat stress- and heat shock transcription factor-dependent expression and activity of ascorbate peroxidase in Arabidopsis

Since the cellular synthesis of glutathione is ATP-dependent, decreased ETC activity also undermines glutathione synthesis, further exacerbating oxidative stress in a vicious cycle [8]