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The carboxyl-terminal fragment of hGH corresponding to amino acids 177191 (AOD9604) was shown to act as a lipid mobilizing domain with inhibitory action on acetyl-CoA carboxylase (ACC) activity in hepatocytes and adipocytes

The dual agonism of GLP1 and GIP receptors improves glycemic control and results in significantly greater weight loss than GLP1 receptor agonism alone. Frias et al., New England Journal of Medicine Other Mechanisms Supporting Fat Loss and Metabolic Health Delays gastric emptying slows digestion and prolongs fullness Reduces appetite fewer calories consumed naturally Increases insulin sensitivity better glucose disposal, reduced fat storage Suppresses glucagon secretion decreases hepatic glucose production These combined mechanisms make tirzepatide an exceptionally powerful tool for weight loss , especially in individuals with impaired glucose control or insulin resistance