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Methods All animal experiments were approved by the Regierung von Oberbayern (ROB-55.22532.Vet_02-19163) and were performed in accordance with the German Animal Welfare Act and Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes

DNA topoisomerase targets of the fluoroquinolones: a strategy for avoiding bacterial resistance

Weve shown these cells reach the brain intact. Two pathways make this possible: The Olfactory Pathway: Provides rapid, direct access to the brain through extracellular transport, with therapeutic agents reaching the olfactory bulb within minutes of administration

GSH deficiency or a decrease in the GSH/glu-tathione disulfide ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in diseases, such as cancer, Parkinson's disease, and Alzheimer's disease