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By identifying HIF-1 as a central regulator of both copper metabolism (via MT2A) and mitochondrial vulnerability (via PDK1/3-DLAT), the authors provide a mechanistic basis for targeting the hypoxia-cuproptosis axis

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Hashimoto's thyroiditis affects 5% of the population and is the leading cause of underactive thyroid, while Graves' disease causes 70% of overactive cases, both being autoimmune conditions