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However, individuals with specific medical conditions should consult their healthcare provider before undergoing treatment

It is the addition of the third oxygen atom that makes ozone supercharged oxygen, and gives it all of its remarkable medical properties

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Supplementary material The Supplementary Material for this article can be found online at: Glossary PGE2 Prostaglandin E2 NF-B Nuclear Factor kappa-B COPD Chronic Obstructive Pulmonary Disease ALI Acute Lung Injury ARDS Acute Respiratory Distress Syndrome ENaC Epithelial Sodium Channel AFC Alveolar Fluid Clearance cGMP Cyclic Guanosine Monophosphate LPS Lipopolysaccharide IL-6 Interleukin-6 TNF- Tumor Necrosis Factor alpha CLP Cecal Ligation and Puncture ROS Reactive Oxygen Species GSH Glutathione SOD Superoxide Dismutase MDA Malondialdehyde HMGB1 High-Mobility Group Box 1 iNOS Inducible Nitric Oxide Synthase GSDMD-N Gasdermin D-N gasdermin D TRAIL Tumor Necrosis Factor-related Apoptosis-inducing Ligand DR5 Death Receptor five NLRP3 NOD-like Receptor Protein 3 LIMK1 LIM Kinase 1 NSCLC Non-Small Cell Lung Cancer EGFR Epidermal Growth Factor Receptor PD-L1 Programmed Death-Ligand 1 STAT3 Signal Transducer and Activator of Transcription 3 miR-34a MicroRNA-34a circRNA Circular RNA Tregs regulatory T cells IPF Idiopathic pulmonary fibrosis ILD interstitial lung disease PLA2 Phospholipase A2 GABAAR -Aminobutyric acid sub-type A receptors CS Cigarette Smoke NOX4 NADPH oxidase four Ca+ Calcium ions CYP2A13 Cytochrome P450 family 2 subfamily A member 13 Keap1 Kelch-like ECH-associated protein 1 SIRT6 Sirtuin 6 Nrf2 Nuclear factor erythroid 2-related factor 2 PGC1 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha SOD2 Superoxide dismutase 2 SOD1 Superoxide dismutase 1 ACE2 angiotensin-converting enzyme 2 TMPRSS2 Transmembrane Protease serine 2 ISG interferon-stimulated genes MRSA methicillin-resistant staphylococcus aureus SARS-CoV-2 severe acute respiratory syndrome coronavirus