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Indeed, the transcription activity of the ARE motif was significantly induced by DMF treatment while ARE motif mutants showed reduced activities (Supplementary Fig

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Collectively, NAD + exerts its effects not through traditional receptor binding but through its indispensable role as a co-substrate and regulator of these enzymatic systems, which sense and respond to fluctuations in NAD + levels to coordinate cellular metabolism, survival, DNA repair, signaling, and cell fate decisions 1-4

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