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Mus81-mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair

The cGMP signalling pathway, which plays a central role in vasodilatation and smooth muscle relaxation, is disrupted in mice lacking CSE

Future studies need to move beyond the linear explanatory framework based on a single metabolite or a single enzyme and systematically clarify, from the perspectives of temporal resolution and tissue niche resolution, the cooperative relationships between different amino acid metabolic axes and the TCA cycle, OXPHOS, and other immunometabolic modules (139)

DOI: 10.1038/345224a0 Schle, R., Umesono, K., Mangelsdorf, D.J., Bolado, J., Pike, J.W., Evans, R.M