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Treatment of B6 mice with the GLS1 inhibitor BPTES significantly reduced histological scores in the spinal cord of affected animals, lowered the number of CD4 + T cells, IL-17A and IFN-producing CD4 + T cells in the spinal cord, substantially decreased clinical scores and weight loss, and ameliorated experimental autoimmune encephalomyelitis (47)

Studies have also investigated its potential applications for Alzheimers disease and other neurodegenerative conditions

In 2012, almost half of the National Institute of Health's funding was allocated to testing that involved animal use (201)

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