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We summarize mechanistic insights across cellular and molecular domains, critically appraise preclinical and clinical findings, and discuss translational challenges that include bioavailability and brain penetration, study heterogeneity, biomarker guided stratification, and pediatric safety

J Pulm Respir Med

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Interestingly, the long-period phenotype in FBXL3 mutants is rescued by REV-ERB deletion, indicating that FBXL3 also promotes circadian period determination and clock robustness by influencing REV-ERB stability and transcriptional activity (Shi et al., 2013)