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Other causes can include multiple sclerosis, tumors, or facial trauma, although these are less common

It is, therefore, possible that in some patients with PIMD, there are some pre-existing genetic risk factors (first hit), and certain peripheral trauma reduced the threshold of manifestation of PIMD (second hit)

Unlike full hGH, AOD 9604 is modified (with a tyrosine residue added) to enhance stability and specifically target fat metabolism without promoting cell growth or insulin-like effects

But if the goal is to study broad improvements in metabolic flexibility, insulin signaling, and overall cellular energy, MOTS-c provides a more comprehensive, systemic approach