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Dominguez LJ et al

Dietary modulation critically impacts this axis: high-fat/low-fiber diets induce microbial dysbiosis that amplifies mesenteric lymph node lymphocyte proliferation and accelerates plaque formation (125, 126).These findings underscore the importance of gut microbiota-immune interactions in atherosclerosis, offering insights into therapeutic strategies targeting the gut microbiome

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We obtained a mutant strain containing the ifd-1(ok2404) deletion (1863 base pairs deleted) and used CRISPR/Cas9 technology to generate deletion allele ifd-2 ( bz187) , which is missing the ifd-2 start codon and the first three ifd-2 exons are affected