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10.1038/srep41356 62 KlingenbergC.KornelisseR

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While profoundly effective for severe acne, the compounds systemic mechanism produces widespread reported adverse events in literature including severe dryness of the lips (cheilitis), skin fragility (xeroderma), dry eyes, increased sun sensitivity, and more seriously teratogenicity (birth defects requiring mandatory pregnancy prevention programs), associations with mood changes and depression in some patients, and emerging research linking it to potential long-term sexual reported adverse events in literature