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Its worth noting that the risk of side effects may vary from person to person, and some individuals may not experience any adverse reactions

Furthermore, microbiota-derived amino acid metabolism is a crucial factor suggesting major perturbations of the microbiome

The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]

Studies have also tested higher doses without adverse reactions , which means that even higher doses can be considered as safe