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Physician guidance on topical frequency and coverage area is important because excessive copper delivery to large skin surface areas carries a theoretical accumulation risk

From initial gastrointestinal protection studies, the research expanded to include wound healing, musculoskeletal repair, neurological effects, cardiovascular applications, and cytoprotection against various toxins [2]

Salles AG, da Costa EF, Ferreira MC, do Nascimento Remigio AF, Moraes LB, Gemperli R (2015) Epidemiologic overview of synkinesis in 353 patients with longstanding facial paralysis under treatment with botulinum toxin for 11 years

A., & Takai, D