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GLP-1 agonists influence the gut by slowing motility as part of their systemic metabolic and appetite-regulating function

This promotes greater metabolic efficiency and shifts the body toward fat oxidation over fat storage

This correlation is believed to be due to widespread autoimmune processes, such as destruction of thyroid follicular cells and epidermal melanocytes by cytotoxic CD8 T cells and increased levels of antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TG) antibodies in patients with vitiligo

But, she adds, "B12 levels, particularly holotranscobalamin levels, likely play a contributory role." The links among Alzheimer's risk, homocysteine, and B12 were more pronounced in older individuals, the study found