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1D shows mitochondrial ROS assessed in HT-1080 cells treated for 6 hours with erastin+/ DFO, as above, or with rotenone (250 nM)+/ DFO

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La hiptesis editorial de KRECE, y la que Pickart defendi desde el principio, es que parte de lo que llamamos envejecimiento cutneo es la consecuencia funcional de que una molcula de sealizacin deje de estar presente en las concentraciones necesarias para sostener la reparacin