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doi: 10.1038/s41561-018-0080-1 248 HwangG.-J.XieH.WahB

Xian ZY, Hu B, Wang T, Cai JL, Zeng JY, Zou Q, et al

Gul A, Rahman MA, Salim A, Simjee SU

Although HO-1 is commonly associated with cytoprotection and inhibition of cell death processes, excessive activation of HO-1 releases large amounts of Fe 2+ , leading to the accumulation of unstable iron pools and corresponding deleterious cyclic effects that exacerbate oxidative stress, presenting a dual effect that characterizes HO-1 as a double-edged sword