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doi: 10.1038/s41598-019-46333-2 206 HanMLeeDLeeSHKimTH

Helices S1S4 are similar to the voltage-sensing domain of voltage-gated cation channels and together form a pVSD (pseudo-voltage-sensing domain) as they lack bona fide voltage sensing

K-KL: Investigation, Validation, Visualization, Writingreview and editing

Binding to ocular melanin reportedly can increase brimonidine s absorption and retention based on its marked affinity for melanin-containing ocular tissues in vitro [231]