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The Dickey laboratory then used an aerosolized version in a mouse model to confirm the drug reduced mucin secretion and airway blockage by mucus

Omar SM, Ahmed MM, Khalil OA, Mady MM

Indeed, decreased GSDME expression in oral squamous cell carcinoma (OSCC) is associated with poor prognosis (176).Thus, this evidence suggests that GSDME mediated pyroptosis plays an essential role in tumor suppression

534,535,536,537 In addition to the two marketed drugs summarized in the previous section, tazemetostat (EPZ-6438) and valemetostat (DS-3201b), numerous novel EZH2 inhibitors are under investigation, with several advances in clinical studies, particularly compounds featuring the 2-pyridone moiety which encompass both bicyclic heteroaromatic and monocyclic aromatic rings