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Dihydroartemisinin remodels tumor micro-environment and improves cancer immunotherapy through inhibiting cyclin-dependent kinases

After four weeks, those treated with Pycnogenol, at dosages of either 150 mg or 100 mg daily, had increased cochlear blood flow in the affected ear and reduced tinnitus severity, and the effects were more pronounced in those receiving the higher dosage

Also, the addition of pharmacodynamic markers (including serum, cellular, or tissue concentrations of TNF-alpha and IL-8) might boost the predictive performance of models and, eventually, control the disease with a significant improvement in quality of life (QOL)

10.1016/s0165-0327(97)00134-1 J