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The main symptoms of Fabry disease are diverse and include angiokeratomas, sweating abnormalities (hyper- or hypohidrosis, anhidrosis), lymphedema [7], acroparesthesias, hearing loss, tinnitus, proteinuria, renal failure, arrhythmias, angina, left ventricular hypertrophy, strokes, abdominal pain and diarrhoea[5, 8] (Fig

As a result, the central nervous system becomes hyper-reactive, amplifying normal sensory inputs into severe, nociplastic pain

Among these, nanoparticles have been widely utilized to enhance the transport of quercetin and other natural and synthetic compounds (Lai et al., 2015)