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Circumference Measurements: Weekly measurements of waist, hips, thighs, and arms using consistent technique (same time of day, same measurement points) track regional changes that correlate with fat loss

While semaglutide is frequently touted as a miracle weight loss drug on social media, it may cause side effects like fatigue and brain fog or gastrointestinal issues like nausea, diarrhea, and constipation (5)

In addition to stating that estimands should be used, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines also emphasize the importance of considering intercurrent events when defining the scientific question of interest and underline key principles for handling missing data [3]