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10.1016/j.freeradbiomed.2018.05.093 52

Moreover, this reinforces the fact that GSH depletion modulates only physiological relevant stimuli as P 2 Y receptors activation and oxidative stress

There is not enough evidence to conclude that smaller doses reliably produce the same clinical effects as larger doses of other forms

Because of this rapid degradation, it was widely believed that oral glutathione had extremely poor bioavailability (often estimated at less than 5%) and could not effectively raise systemic intracellular stores