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Notably, structure-based drug design targeting novel lactylation sitesparticularly when integrated with established immunotherapies such as checkpoint inhibitors (anti-PD-1/anti-CTLA-4 antibodies) and CAR-Tconstitutes a rationally prioritized therapeutic strategy to augment antitumor responses, representing a critical frontier warranting systematic interrogation

The pathway analysis in this study also demonstrated that PD was one of the most significantly altered pathways after riboflavin deficiency

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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Khavinson V.K., Zemchikhina V.N., Trofimova S.V., Malinin V.V