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Early AD was reported to lead to a substantial increase in the quantity of 3-nitrotyrosine residues in proteins, including nitrosylated GDH, whose function is significantly diminished in some patients with early AD (Reed et al., 2009)

Osborn MJ, Freeman M, Huennekens FM (1958) Inhibition of dihydrofolic reductase by aminopterin and amethopterin

Abstract Many local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart disease and stroke, cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 19 (COVID-19), involve both, (1) oxidative stress with excessive production of reactive oxygen species (ROS) that lower glutathione (GSH) levels, and (2) inflammation

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