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Belmont, CA: Wadsworth 2005 p

5.3 The gut barriersystemic inflammation axis: a common convergence endpoint and mechanistic landing point across modules 5.3.1 Module positioning: why it serves as a common endpoint For the functional outputs of different metabolic modules to influence synovial inflammation and structural damage, they likely traverse a common conduit: Gut Barrier Permeability AlterationSystemic Inflammation AmplificationPeripheral Immune Activation. (Liu et al., 2018)

Because of the risks of corporal rupture or other serious penile injury, XIAFLEX is available for the treatment of Peyronies disease only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the XIAFLEX REMS Program