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GOF mutations in STAT1 and STAT3 cause hyperactivation in STAT1 and STAT3 respectively

Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium levels

The research also identified a mutation in DNMT3B leading to the mislocalization of H3K4me1 activity, resulting in hypermethylation of active promotersa finding closely related to the immunodeficiency phenotype of ICF syndrome, particularly in genes involved in B-cell receptor-mediated maturation pathways (51)

Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: possible involvement of TRPM2 channels