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Although energy metabolism status can also regulate intracellular ROS levels (e.g., glucose deprivation leads to a marked increase in cellular ROS) [53,54,55,56], our study demonstrated that supplementation with energy substrates such as sodium pyruvate in GGCT-knockdown cell models did not induce significant alterations in intracellular ROS levels

However, the etiology and clinical impact of glycine deficiency in obesity may differ from other diseases, and dietary glycine supplementation has not been used to treat individuals with severe obesity